Acetylated methylmannose polysaccharide of Streptomyces.
نویسندگان
چکیده
منابع مشابه
Occurrence of polysaccharide granules in sporulating hyphae of Streptomyces viridochromogenes.
Evidence of the presence of polysaccharide polymers is shown in Streptomyces sp. for the first time. Cytochemical methods revealed the occurrence of polysaccharide granules in sporulating hyphae of Streptomyces viridochromogenes. Onset of the sporogenesis coincided with the appearance of the granules, which reached a maximum number during the early stages of maturation. The later stages of matu...
متن کاملStructural investigation of an antibacterial polysaccharide from Streptomyces virginia H03.
The chemical structure of a polysaccharide from the broth of cultured Streptomyces virginia H03 was investigated. There might be 1-->2 and 1-->4 and no 1-->6 glycosidic linkages in the polysaccharide according to periodate oxidation and Smith degradation. Four fragments including 2,3,4,6-Me4-Man, 2,3,6-Me3-Gal, 2,4,6-Me3-Glc, and 3,6-Me2-Man were found in the methylated polysaccharide. Furtherm...
متن کاملPhase I clinical trial of O-acetylated pectin conjugate, a plant polysaccharide based typhoid vaccine.
BACKGROUND Typhoid fever remains an important cause of morbidity and mortality in the developing countries. Vi capsular polysaccharide conjugate vaccine demonstrated safety and efficacy in young children in high endemic regions. A novel typhoid conjugate vaccine based on plant polysaccharide pectin was studied in a phase I trial. METHODS Fruit pectin, having the same carbohydrate backbone str...
متن کاملEvaluation of De-O-acetylated meningococcal C polysaccharide-tetanus toxoid conjugate vaccine in infancy: reactogenicity, immunogenicity, immunologic priming, and bactericidal activity against O-acetylated and De-O-acetylated serogroup C strains.
The polysaccharide capsule of serogroup C Neisseria meningitidis (MenC) has been integral to vaccine development. Licensed MenC vaccines contain the O-acetylated (OAc+) form of polysaccharide. Some MenC strains have de-O-acetylated (OAc-) polysaccharide, which may affect antibody specificity and functional activity when used in a vaccine. We evaluated an OAc-MenC conjugate-tetanus toxoid conjug...
متن کاملComponents and antioxidant activity of the polysaccharide from Streptomyces virginia H03.
A polysaccharide was isolated from the broth of cultured Streptomyces virginia H03 which was treated by ethanol deposition and savage method to remove the protein, and was purified using Sephadex G-150 column chromatography. The components of the polysaccharide were determined by gas chromatography. The purified polysaccharide was made up of mannose, glucose and galactose, in a 2:1:1 proportion...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1977
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)40482-0